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Schistosomiasis & NTD Control

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In order to achieve our goals SCI collaborates with international agencies, governmental and non-governmental organizations, bi-lateral and multi-lateral agencies, NGOs, Foundations, the media, pharmaceutical companies and the private sector in order to mobilise resources against NTDs.

In 2006, the World Health Organization (WHO) announced a major shift in its strategy for the control of NTDs away from recommending interventions aimed at “specific diseases” to helping the “maximum number of people at risk who could be treated with a set of drugs”. The seven NTDs share characteristics that allow for a sychronised and integrated treatment strategy. There are five drugs (collectively referred to as the ‘Rapid Impact Package’) required to treat all seven NTDs and the majority are donated through a designated program set up by the pharmaceutical manufacturers. The drug donations themselves are valued at over US $1 billion, and represent the largest drug donation in history.

Disease

Drug (Donor)

Price

Onchocerciasis Ivermectin (Merck) Merck have committed to supply
all that is needed.
Soil-Transmitted
Helminths
Mebendazole
(Johnson&Johnson)
or Albendazole
J&J will donate approx. 100
million tablets of Mebendazole
per year. Various suppliers of
Albendazole at 1p/2¢ per tablet.
Trachoma Azythromycin
(Pfizer)
Donated to National
Governments by Pfizer through
the International Trachoma
Initiative (ITI)
Lymphatic
Filariasis
Ivermectin (Merck)
+ Albendazole
(GlaxoSmithKline)
Merck and GSK combine to offer
free treatment to over 200
million people at risk.
Schistosomiasis Praziquantel
(partial
donation from E.
Merck
and MedPharm)
16 million tablets per year of
Praziquantel are donated by
MedPharm and 200 million
tablets over the next 10 years by
E. Merck. The remainder is
purchased at 4p/8¢ per tablet.

In the field we use a strategy called ‘Community Based Treatment’ (CBT) in order to successfully distribute the Rapid Impact Package of drugs to those who suffer from NTDs. The drugs are easy to administer so non-medically trained staff can be trained to deliver the drugs by attending a one day course. The advantage of the CBT approach is that it empowers local communities through ‘ownership’ of the health scheme and ensures a higher uptake and longevity of the programme. Wherever possible through collaboration with the Ministry of Education schools are used as centres for treatment. They offer an extensive infrastructure with a skilled workforce already established in the community to administer the treatment. Teachers and Community Drug Distributors (CDDs are chosen by their community) are trained to distribute drugs to the targeted at risk population. Teachers and CDDs are perceived by the community as those possessing attributes of honesty, good conduct, integrity, trustworthiness and good record keeping.

Unlike the majority of drug treatments the drugs used to treat NTDs are safe regardless of whether or not the person is infected. This removes the necessity and huge financial burden of individual screening. Furthermore, the drugs are easy to store, do not require refrigeration and last for up to 4 years. This allows us to buy drugs in bulk, reducing the cost per unit significantly. Collectively these factors allow SCI to deliver treatment cheap and effective treatment for NTDs across sub-Saharan Africa.
 

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© Schistosomiasis Control Initiative 2008

Department of Infectious Disease Epidemiology
Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG

email:
schisto@imperial.ac.uk